Tri-Luma® Cream

Tri-Luma® CreamTri-Luma® is the only FDA-approved melasma treatment with 3 active ingredients, uniquely combined and more effective than treatments containing only two of the ingredients.

Tri-Luma® Cream is a unique triple-combination topical therapy for the short-term (8-week ) treatment of the dark spots associated with moderate-to-severe facial melasma.

  1. Fluocinolone acetonide 0.01% is a mild corticosteroid that reduces inflammation.
  2. Hydroquinone 4% is a depigmenting agent that interrupts the formation and synthesis of melanin to help lighten the skin.
  3. Tretinoin 0.05% works by increasing the skin cell turnover rate, which helps exfoliate the skin.

Tri-Luma® Cream should always be used in conjunction with sun-avoidance measures, like using sunscreens and wearing protective clothing. Tri-Luma® may improve the appearance of melasma but is not a cure.

How to apply Tri-Luma® Cream

Tri-Luma® Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) should always be used as instructed by your doctor. To use the medicine correctly, follow these steps:

  • Apply Tri-Luma® Cream at night, at least 30 minutes before bedtime.
  • Gently wash your face with a mild cleanser. Don’t use a washcloth to apply the cleanser, just your fingers. Rinse and pat your skin dry.
  • Put a small amount (pea sized or ½ inch or less) of Tri-Luma® Cream on your fingertip. Apply a thin coat onto the discolored spot(s). Include about ½ inch of normal skin surrounding the affected area.
  • After you have used the medicine for a while, you may find that you need slightly less to do the job.
  • Rub the medicine lightly and uniformly into your skin. The medicine should become invisible almost at once. If you can still see it, you are using too much.
  • Keep the medicine away from the corners of your nose, your mouth, eyes and open wounds. Spread it away from those areas when applying it.
  • Do not use more Tri-Luma® Cream or apply it more often than recommended by your doctor. Too much Tri-Luma® Cream may irritate your skin and won’t give you faster or better results.
  • Do not cover the treated area with anything after applying Tri-Luma® Cream.
  • During use of Tri-Luma® Cream, you may experience redness, peeling, burning, dryness, itching or other skin irritation. If your skin gets too irritated, stop using Tri-Luma® Cream, and let your doctor know. Tri-Luma® Cream may also cause a gradual blue-black darkening of your skin; if this happens, stop using the product immediately and speak to your doctor. To help avoid skin dryness, you may use a moisturizer in the morning after you wash your face.
  • You may also use a moisturizer and cosmetics during the day.

Use a sunscreen of at least SPF 30 and a wide-brimmed hat over the treated areas. It requires only a small amount of sunlight—not just a sunburn—to worsen melasma. If you do get sunburned, stop using Tri-Luma® Cream until your skin is healed. After stopping treatment with Tri-Luma® Cream, continue to protect your skin from sunlight.

Only your doctor knows which other medicines may be helpful during treatment and will tell you about them if needed. Do not use other medicines unless your doctor approves them.

What to avoid while using Tri-Luma® Cream

You should avoid sunlight and ultraviolet light. Tri-Luma® Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) can make your skin more likely to get sunburned or develop other unwanted effects from natural or artificial sunlight (as from a sunlamp or tanning bed). Dark skin patches may also become darker when your skin is exposed to sunlight. Any level of sun exposure can contribute to or trigger melasma—you don’t have to be sunburned to make your melasma worse.

It is important to protect your skin from the sun to help prevent further darkening of existing dark patches and the formation of new ones.

Staying out of the sun is especially important for women who take birth control pills or hormone replacement therapy, and for people who have had dark patches in the past.

Follow these guidelines regarding sun exposure when using Tri-Luma® Cream:

  • Use an effective sunscreen any time you are outside, even on hazy days. The sunscreen should have an SPF (sun protection factor) of 30 or more. Use sunscreen year-round on areas of the skin that are regularly exposed to sunlight, such as your face and hands. If possible, protect the treated area from sunlight exposure.
  • If you spend a lot of time outside, be especially careful of sunlight. Ask your doctor what SPF level will give you the needed high level of protection. If you will be outside, wear protective clothing, including a hat.
  • Do not use sunlamps or any artificial source of sunlight (such as tanning beds) while you use Tri-Luma® Cream.

Skin treated with Tri-Luma® Cream may be more likely to react to heat and cold than untreated skin. Your doctor can recommend ways to manage your melasma under these conditions.

While using Tri-Luma® Cream, you should avoid products that may dry or irritate your skin. These may include soaps and cleansers that are rough or cause dryness; certain astringents, such as alcohol-containing products, soaps and toiletries containing alcohol, spices, or lime; or certain medicated soaps, shampoos, and hair permanent products.

Do not use any other medicines with Tri-Luma® Cream unless you have consulted your doctor. The medicines and products you have used in the past may cause redness or peeling when used with Tri-Luma® Cream.

$125.00